La Jolla Bioengineering Institute

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John A. Frangos, PhD


President & CEO, Scientific Director
La Jolla Bioengineering Institute
La Jolla, CA




  • Rice University, Ph.D. 1986 Chemical Engineering
  • Stanford University, M.S. 1982 Chemical Engineering
  • Johns Hopkins University, B.S. 1981 Chemical Engineering

  • 2002 Present Founder, Scientific Director, President & CEO, La Jolla Bioengineering Institute.
  • 1996 2002 Professor, Department of Bioengineering, University of California San Diego.
  • 1994 1996 Associate Professor, Department of Bioengineering, University of California San Diego.
  • 1992 1994 Associate Professor, Department of Chemical Engineering, Penn State University.
  • 1986 1992 Assistant Professor, Department of Chemical Engineering, Penn State University.

Honors and Memberships
  • 2009 2014 NIH MERIT Award
  • 2002 2004 Member, Surgery and Bioengineering Study Section, NIH
  • 1999    Fellow, American Institute for Medical and Biological Engineering
  • 1997 1998 Editorial Board, American Journal of Physiology: Heart and Circulatory Physiology
  • 1998 Present Editorial Board, General Pharmacology
  • 1998 2001 American Heart Association Study Committee on Vascular Wall Biology I
  • 1998 Present External Advisory Board, Program on Mechanotransduction in Bone, Indiana Univ
  • 1997 2000 External Advisory Board, NSCORT on Space Cell Biology, Rice University
  • 1997 2000 Board of Directors, Biomedical Engineering Society
  • 1997    Program Chair, Annual meeting of Biomedical Engineering Society, San Diego
  • 1997    Board of Scientific Counselors, Nat. Inst. on Deafness & Other Communication Disorders
  • 1993    Y.C. Fung Young Investigator Award, American Society of Mechanical Engineers
  • 1993 1996 Councilor, North American Society of Biorheology
  • 1990 1995 NSF Presidential Young Investigator Award
  • 1991     Outstanding Research Award, College of Engineering, Penn State University



Selected Publications

Microfluidic enhancement of intramedullary pressure increases intersitital fluid flow and inhibits bone loss in hindlimb suspended mice.


Kwon RY, Meays DR, Tang WF, Frangos JA.
J Bone Miner Res. 2010 Feb 23.

Rapid changes in shear stress induce dissociation of a G alpha(q/11)-platelet endothelial cell adhesion molecule-1 complex.


Laura A Otte, Kelly S Bell, Laurent Loufrani, Jiunn-Chern Yeh, Benoit Melchior, Diep N Dao, Hazel Y Stevens, Charles R White & John A Frangos
The Journal of physiology. 2009 May;

PECAM-1 is a critical mediator of atherosclerosis. Disease Models Mechanisms.


Hazel Y Stevens, Benoit Melchior, Kelly S Bell, Sujin Yun, Jiunn-Chern Yeh & John A Frangos
Disease models & mechanisms. 2008 Sep-Oct ; 1(2-3):175-81; discussion 179

Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.


Jiunn-chern Yeh, Laura A Otte & John A Frangos
Biochemistry. 2008 Aug;

Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols.


Dennis H Kim & John A Frangos
Biophysical journal. 2008 Jul;

Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.


Irene Gramaglia, Peter Sobolewski, Diana Meays, Ramiro Contreras, John P Nolan, John A Frangos, Marcos Intaglietta & Henri C van der Heyde
Nature medicine. 2006 Dec; 


Complete List

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